中央气道

2004年毕业于中山大学，毕业后一直从事呼吸科专业，现任呼吸介入中心副主任，从事呼吸系统疾病及肿瘤研究近20年，擅长气道内介入手术，气管、支气管狭窄内镜治疗，肺部小结节的精准诊断。

代表性科研项目：

1. 国家自然科学基金专项项目：应对大规模呼吸传染病检疫的智能化视力融合采样方法研究

2. 国家自然科学基金重大研究计划：呼吸道传染病应急检疫机器人基础理论及关键技术研究

3. 广东省基础与应用基础研究：基于OCT技术对COPD、哮喘和哮喘-COPD重叠的小气道结构及对病情评估机制

4. 广东省自然科学基金：基于气道内OCT抗IgE治疗重症哮喘改善气道重构作用的机制研究。

代表性学术论文（参考文献格式）：

1. Chen Y, Zhou ZQ, Feng JX, Su ZQ, Zhong CH, Lu LY, Chen XB, Tang CL, Digumarthy SR, Fiorelli A, Natour E, Lococo F, Petrella F, Harris K, Nakada T, Zhong NS, Li SY. Hybrid stenting with silicone Y stents and metallic stents in the management of severe malignant airway stenosis and fistulas. Transl Lung Cancer Res. 2021 May;10(5):2218-2228. doi: 10.21037/tlcr-21-353. PMID: 34164271; PMCID: PMC8182715.

2. Zhou C, Li S, Liu J, Chu Q, Miao L, Cai L, Cai X, Chen Y, Cui F, Dong Y, Dong W, Fang W, He Y, Li W, Li M, Liang W, Lin G, Lin J, Lin X, Liu H, Liu M, Mu X, Hu Y, Hu J, Jin Y, Li Z, Qin Y, Ren S, Sun G, Shen Y, Su C, Tang K, Wu L, Wang M, Wang H, Wang K, Wang Y, Wang P, Wang H, Wang Q, Wang Z, Xie X, Xie Z, Xu X, Xu F, Yang M, Yang B, Yi X, Ye X, Ye F, Yu Z, Yue D, Zhang B, Zhang J, Zhang J, Zhang X, Zhang W, Zhao W, Zhu B, Zhu Z, Zhong W, Bai C, Chen L, Han B, Hu C, Lu S, Li W, Song Y, Wang J, Zhou C, Zhou J, Zhou Y, Saito Y, Ichiki Y, Igai H, Watanabe S, Bravaccini S, Fiorelli A, Petrella F, Nakada T, Solli P, Tsoukalas N, Kataoka Y, Goto T, Berardi R, He J, Zhong N. International consensus on severe lung cancer—the first edition. Transl Lung Cancer Res 2021;10(6):2633-2666. doi: 10.21037/tlcr-21-467

3. Zhou ZQ, Feng JX, Chen Y, Su ZQ, Zhong CH, Chen XB, Tang CL, Huang JR, Li SY. Self-expanding covered metallic stents as a transition to silicone stent implantation in management of severe post-tuberculosis bronchial stenosis. Ther Adv Respir Dis. 2021, Vol. 15: 1–10.doi: 10.1177/17534666211019564. PMID: 34044660; PMCID: PMC8165876.

4. Chen DF, Chen Y, Zhong CH, Chen XB, Li SY. Long-term efficacy and safety of the Dumon stent for benign tracheal stenosis: a meta-analysis. J Thorac Dis. 2021 Jan;13(1):82-91. doi: 10.21037/jtd-20-2327. PMID: 33569188; PMCID: PMC7867818.

5. Qiu M, Wei S, Lai Z, Huang P, Wang Z, Zhong C, Chen Y, Zhang X, Lin X, Zeng Q, Chung KF, Zhang Q, Xie J, Li S. Early radiologic and bronchoscopic changes after bronchial thermoplasty in patients with severe asthma. Exp Ther Med. 2020 Dec;20(6):278. doi: 10.3892/etm.2020.9408. Epub 2020 Oct 27. PMID: 33200003; PMCID: PMC7664609.

6. Zhou ZQ, Su ZQ, Sun W, Zhong ML, Chen Y, Zhong CH, Chen HJ, Li SY. Postintubation Tracheal Stenosis Evaluated by Endobronchial Optical Coherence Tomography: A Canine Model Study. Respiration. 2020;99(6):500-507. doi: 10.1159/000506882. Epub 2020 Jun 2. PMID: 32485723.

7. Yao Y, Su Z, Chen Y, Ye Y, Lu L, Zhong C, Chen X, Tang C, Li S. Safety and efficacy of sufentanil combined with midazolam in bronchoscopy under conscious sedation: retrospective study of 11,158 cases. J Thorac Dis. 2019 Oct;11(10):4127-4134. doi: 10.21037/jtd.2019.10.03. PMID: 31737295; PMCID: PMC6837946.

8. Su ZQ, Guan WJ, Li SY, Feng JX, Zhou ZQ, Chen Y, Zhong ML, Zhong NS. Evaluation of the Normal Airway Morphology Using Optical Coherence Tomography. Chest. 2019 Nov;156(5):915-925. doi: 10.1016/j.chest.2019.06.009. Epub 2019 Jun 29. PMID: 31265836.

9. Zhou ZQ, Zhong CH, Su ZQ, Li XY, Chen Y, Chen XB, Tang CL, Zhou LQ, Li SY. Breathing Hydrogen-Oxygen Mixture Decreases Inspiratory Effort in Patients with Tracheal Stenosis. Respiration. 2019;97(1):42-51. doi: 10.1159/000492031. Epub 2018 Sep 18. PMID: 30227423.

10. Qiu M, Lai Z, Wei S, Jiang Q, Xie J, Qiu R, Wang Z, Zhong C, Chen Y, Zhang Q, Li S, Zhong N. Bronchiectasis after bronchial thermoplasty. J Thorac Dis. 2018 Oct;10(10):E721-E726. doi: 10.21037/jtd.2018.09.116. PMID: 30505510; PMCID: PMC6236163.

11. Su ZQ, Guan WJ, Li SY, Ding M, Chen Y, Jiang M, Chen XB, Zhong CH, Tang CL, Zhong NS. Significances of spirometry and impulse oscillometry for detecting small airway disorders assessed with endobronchial optical coherence tomography in COPD. Int J Chron Obstruct Pulmon Dis. 2018 Oct 1;13:3031-3044. doi: 10.2147/COPD.S172639. PMID: 30319251; PMCID: PMC6171757.

12. Su Z, Zhong C, Li S, Chen X, Chen Y, Tang C. Needle-based confocal laser endomicroscopy in the diagnosis of peripheral pulmonary nodule: a preliminary report. J Thorac Dis. 2017 Aug;9(8):2608-2612. doi: 10.21037/jtd.2017.06.10. PMID: 28932568; PMCID: PMC5594183.

13. Su Z, Li S, Zhou Z, Chen X, Gu Y, Chen Y, Zh0ong C, Zhong M, Zhong N. A canine model of tracheal stenosis induced by cuffed endotracheal intubation. Sci Rep. 2017 Mar 28;7:45357. doi: 10.1038/srep45357. PMID: 28349955; PMCID: PMC5368979.

14. Guo WL, Zhou ZQ, Chen L, Su ZQ, Zhong CH, Chen Y, Li SY. Serum KL-6 in pulmonary alveolar proteinosis: China compared historically with Germany and Japan. J Thorac Dis. 2017 Feb;9(2):287-295. doi: 10.21037/jtd.2017.02.14. PMID: 28275476; PMCID: PMC5334078.

15. O'Connell OJ, Almeida FA, Simoff MJ, Yarmus L, Lazarus R, Young B, Chen Y, Semaan R, Saettele TM, Cicenia J, Bedi H, Kliment C, Li L, Sethi S, Diaz-Mendoza J, Feller-Kopman D, Song J, Gildea T, Lee H, Grosu HB, Machuzak M, Rodriguez-Vial M, Eapen GA, Jimenez CA, Casal RF, Ost DE. A Prediction Model to Help with the Assessment of Adenopathy in Lung Cancer: HAL. Am J Respir Crit Care Med. 2017 Jun 15;195(12):1651-1660. doi: 10.1164/rccm.201607-1397OC. PMID: 28002683; PMCID: PMC5476908.

16. Chen Y, Khemasuwan D, Simoff MJ. Lung cancer screening: detected nodules, what next? Lung Cancer Manag. 2016 Dec;5(4):173-184. doi: 10.2217/lmt-2016-0008. Epub 2017 Feb 6. PMID: 30643562; PMCID: PMC6310323.

17. Ding M, Chen Y, Guan WJ, Zhong CH, Jiang M, Luo WZ, Chen XB, Tang CL, Tang Y, Jian QM, Wang W, Li SY, Zhong NS. Measuring Airway Remodeling in Patients With Different COPD Staging Using Endobronchial Optical Coherence Tomography. Chest. 2016 Dec;150(6):1281-1290. doi: 10.1016/j.chest.2016.07.033. Epub 2016 Aug 12. PMID: 27522957.

18. Chen X, Chen Y, Zhong C, Zeng Y, Luo W, Li S. The efficacy and safety of airway foreign body removal by balloon catheter via flexible bronchoscope in children - A retrospective analysis. Int J Pediatr Otorhinolaryngol. 2016 Mar;82:88-91. doi: 10.1016/j.ijporl.2016.01.003. Epub 2016 Jan 13. PMID: 26857322.

19. Chen Y, Ding M, Guan WJ, Wang W, Luo WZ, Zhong CH, Jiang M, Jiang JH, Gu YY, Li SY, Zhong NS. Validation of human small airway measurements using endobronchial optical coherence tomography. Respir Med. 2015 Nov;109(11):1446-53. doi: 10.1016/j.rmed.2015.09.006. Epub 2015 Sep 25. PMID: 26427628.

20. 陈愉,周子青,冯家欣,钟长镐,卢丽雅,陈小波,唐纯丽,李时悦. 使用气道内杂交支架治疗复杂气道狭窄和气道瘘疗效与安全性分析[J]. 中国肺癌杂志,2020,23(06):472-478.

21. 苏柱泉,关伟杰,冯家欣,周子青,陈愉,钟明璐,李时悦,钟南山.光学相干断层扫描成像对正常气道结构的定量测量[J].中华结核和呼吸杂志,2020,{4}(02):119.

22. 陈小波,罗群,陈愉,韩茜,钟长镐,萧伟权,苏柱泉,姚遥,李时悦.冷冻肺活检对间质性肺疾病诊断有效性及安全性的前瞻性研究[J].中华结核和呼吸杂志,2018,41(06):467-471.

23. 周子青,郭文亮,陈愉,钟长镐,李时悦.全肺灌洗术治疗肺泡蛋白沉积症围手术期并发症分析[J].中华结核和呼吸杂志,2017,40(07):499-503.

24. 周子青,陈愉,钟长镐,陈小波,唐纯丽,苏柱泉,李时悦.硅酮支架治疗气管支气管结核所致气道狭窄的效果分析(附17例总结).中国防痨杂志,2017,39(3):226-230.

25. 周子青,苏柱泉,唐纯丽,李时悦.局部喷洒曲安奈德联合球囊扩张治疗良性中央气道狭窄疗效研究.新医学,2016,47(11):742-746.

26. 钟长镐,罗为展,唐纯丽,陈小波,陈愉,李时悦.Montgomery T型硅酮支架治疗声门下狭窄术后早期并发症的临床观察[J].中华结核和呼吸杂志,2016,39(12):983-984.

27. 罗为展,钟长镐,陈小波,陈愉,唐纯丽,李时悦.支气管镜超声弹性成像在肺门纵隔淋巴结良恶性的诊断价值[J].国际呼吸杂志,2016,36(11):801-803.

28. 张清玲,张筱娴,谢佳星,邱日皇,陈愉,黄智勇,何颖,鲜墨,李靖,李时悦.支气管热成形术治疗重度支气管哮喘的初步临床观察[J].中华结核和呼吸杂志,2016,39(03):183-188.

29. 唐纯丽,罗为展,钟长镐,童达,陈愉,陈小波,李时悦.径向超声联合虚拟导航引导肺活检对肺外周结节的诊断价值[J].中华结核和呼吸杂志,2016,39(01):38-40.

30. 罗为展,钟长镐,陈愉,陈小波,唐纯丽,李时悦.肺癌体内共聚焦激光显微内镜成像的初步观察[J].中华结核和呼吸杂志,2015,38(10):792-793.

周承志,秦茵茵,陈愉,谢晓鸿,谢展鸿,张洁霞,欧阳铭,李时悦,陈荣昌.经皮穿刺氩氦刀联合化疗治疗晚期非小细胞肺癌合并慢性阻塞性肺疾病患者的疗效观察[J].中国医药指南,2015,13(03):12-13.

获奖及个人荣誉：

2021年荣获广东医学科技奖; 2018年荣获世界介入肺脏病学会青年研究者奖，是首位中国获得者；2018荣获亚太呼吸疾病学会青年奖和广州市高层次人才称号

呼吸介入中心副主任

研究工作：气道内介入手术，气管、支气管狭窄内镜治疗，肺部小结节的精准诊断.